19患者的不同免疫型

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本期文章:《科学》:Online/在线发表

美国宾夕法尼亚大学E. John Wherry等研究人员合作揭示了COVID-19患者的不同免疫型。相关论文于2020年7月15日在线发表在《科学》杂志上。

研究人员分析了125名COVID-19患者,并使用高维细胞计数法将其与健康个体进行了比较。 对约200种免疫和约50种临床特征的综合分析显示,一部分患者的T细胞和B细胞亚群被激活。一组患者具有急性病毒感染的T细胞活化特征,成浆细胞反应达到循环B细胞的30%以上。

 

但是,另一组患者的淋巴细胞活化程度与未感染的受试者相当。研究人员确定了稳定的免疫标记与动态的免疫标记,并将其与疾病严重性变化的轨迹相关联。

 

这些分析确定了三种“免疫型”,它们与不良的临床轨迹和健康状况改善有关。这些免疫型可能对COVID-19的治疗和疫苗设计有影响。

 

附:英文原文

Title: Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Author: Divij Mathew, Josephine R. Giles, Amy E. Baxter, Derek A. Oldridge, Allison R. Greenplate, Jennifer E. Wu, Cécile Alanio, Leticia Kuri-Cervantes, M. Betina Pampena, Kurt D’Andrea, Sasikanth Manne, Zeyu Chen, Yinghui Jane Huang, John P. Reilly, Ariel R. Weisman, Caroline A. G. Ittner, Oliva Kuthuru, Jeanette Dougherty, Kito Nzingha, Nicholas Han, Justin Kim, Ajinkya Pattekar, Eileen C. Goodwin, Elizabeth M. Anderson, Madison E. Weirick, Sigrid Gouma, Claudia P. Arevalo, Marcus J. Bolton, Fang Chen, Simon F. Lacey, Holly Ramage, Sara Cherry, Scott E. Hensley, Sokratis A. Apostolidis, Alexander C. Huang, Laura A. Vella, The UPenn COVID Processing Unit, Michael R. Betts, Nuala J. Meyer, E. John Wherry

Issue&Volume: 2020/07/15

Abstract: AbstractCOVID-19 is currently a global pandemic, but human immune responses to the virus remain poorly understood. We analyzed 125 COVID-19 patients, and compared recovered to healthy individuals using high dimensional cytometry. Integrated analysis of ~200 immune and ~50 clinical features revealed activation of T cell and B cell subsets in a proportion of patients. A subgroup of patients had T cell activation characteristic of acute viral infection and plasmablast responses reaching >30% of circulating B cells. However, another subgroup had lymphocyte activation comparable to uninfected subjects. Stable versus dynamic immunological signatures were identified and linked to trajectories of disease severity change. These analyses identified three “immunotypes” associated with poor clinical trajectories versus improving health. These immunotypes may have implications for the design of therapeutics and vaccines for COVID-19.

DOI: 10.1126/science.abc8511

Source: https://science.sciencemag.org/content/early/2020/07/15/science.abc8511

期刊信息

Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037

官方网址:https://www.sciencemag.org/

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