限时进食可控制体重并改善心脏健康

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本期文章:《细胞—代谢》:Online/在线发表

2020年7月15日,美国伊利诺伊大学Krista A. Varady团队在《细胞—代谢》杂志发表论文,揭示了限时进食对肥胖患者体重和心脏健康的影响。

研究人员进行了第一项人体试验,比较了两种常见的限时进食(TRF)形式(4和6小时)对体重和心脏代谢危险因素的影响。肥胖成年人被随机分为4小时TRF(仅在下午3点至7点之间进食)、6小时TRF(仅在1点至7点之间进餐)或对照组(无进餐时间限制)。

 

8周后,与对照组相比,4小时和6小时TRF产生了一定程度的体重降低(约3%)、胰岛素抵抗和氧化应激。两个TRF组的能量摄入量每天减少约550 kcal/天。

 

这些发现表明4小时和6小时TRF会在8周内引起体重的轻度降低,并有望作为减肥干预措施。这些饮食也可以改善心脏代谢健康的某些方面。

 

据悉,限时进食(TRF)方案已越来越流行。但是,很少有研究探索它们的减肥功效。

 

附:英文原文

Title: Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity

Author: Sofia Cienfuegos, Kelsey Gabel, Faiza Kalam, Mark Ezpeleta, Eric Wiseman, Vasiliki Pavlou, Shuhao Lin, Manoela Lima Oliveira, Krista A. Varady

Issue&Volume: 2020-07-15

Abstract: Time-restricted feeding (TRF) regimens have grown in popularity; however, very fewstudies have examined their weight-loss efficacy. We conducted the first human trial(Clinicaltrials.gov NCT03867773) to compare the effects of two popular forms of TRF(4 and 6 h) on body weight and cardiometabolic risk factors. Adults with obesity wererandomized to 4-h TRF (eating only between 3 and 7 p.m.), 6-h TRF (eating only between1 and 7 p.m.), or a control group (no meal timing restrictions). After 8 weeks, 4-and 6-h TRF produced comparable reductions in body weight (~3%), insulin resistance,and oxidative stress, versus controls. Energy intake was reduced by ~550 kcal/dayin both TRF groups, without calorie counting. These findings suggest that 4- and 6-hTRF induce mild reductions in body weight over 8 weeks and show promise as interventionsfor weight loss. These diets may also improve some aspects of cardiometabolic health.

DOI: 10.1016/j.cmet.2020.06.018

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30319-3

期刊信息

Cell Metabolism:《细胞—代谢》,创刊于2005年。隶属于细胞出版社,最新IF:22.415
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